Black Cumin Seed Oil (Nigella sativa), whose virtues have been extolled since the Pharos, has been reported by multiple studies to exhibit anti-proliferation effect on breast, colon, ovary, larynx, lung, myeloblastic leukemia, and bone cancer cells, as well as inflammation. Studies also showed that black seed oil inhibited the growth of hormone refractory prostate cancer. These studies show the oil can also induce cell death in tumor cells, and inhibits tumor cell development. Most recently, a study identified the sensitizing effect of black cumin seed oil in Pancreatic Cancer cells resistant to Gemcitabine ( a powerful cancer fighting drug). The bioactive compound found in black cumin seed oil is Thymoquinone (TQ). Researchers are optimistic the oil could be an reputable addition to conventional chemotherapeutics.
Note: Studies referred to are located through the Medline Plus research database of the NIH.
1. Banerjee S, Padhye S, Azmi A, et al. Review on Molecular and Therapeutic Potential of Thymoquinone in Cancer. Nutrition and cancer. 2010;62(7):938-946. doi:10.1080/01635581.2010.509832.
2. Linjawi SAA, Khalil WKB, Hassanane MM, Ahmed ES. Evaluation of the protective effect of Nigella sativa extract and its primary active component thymoquinone against DMBA-induced breast cancer in female rats. Archives of Medical Science : AMS. 2015;11(1):220-229. doi:10.5114/aoms.2013.33329.
5. Thymoquinone from nutraceutical black cumin oil activates Neu4 sialidase in live macrophage, dendritic, and normal and type I sialidosis human fibroblast cells via GPCR Galphai proteins and matrix metalloproteinase-9.